CRH and ACTH are tropic hormones because they act on the anterior pituitary gland and adrenal glands, respectively, both of which are endocrine glands. Since cortisol is what finally reaches other tissues in the body, it is a non-tropic hormone. Lastly, cortisol (non-tropic) is secreted from the adrenal glands and goes into the bloodstream where it can have more widespread effects on organs and tissues. This stimulates the anterior pituitary and causes it to release Adrenocorticotropic hormone (ACTH tropic) to the adrenal glands. The reaction begins in the hypothalamus with a release of corticotropin-releasing hormone/factor (CRH/F tropic). The Hypothalamic-pituitary-adrenal axis is a perfect example of this chain reaction. These are the ones that act in the end of the chain reaction on other cells that are not part of other endocrine gland. Tropic hormones usually act in the beginning of the reaction stimulating other endocrine gland to eventually release non-tropic hormones. Non-tropic hormones are those that act directly on targeted tissues or cells, and not on other endocrine gland to stimulate release of other hormones. This differs from the tropic hormones, which act on another endocrine gland. Non-tropic hormones are hormones that directly stimulate target cells to induce effects. Wikipedia Rate this definition: 0.0 / 0 votes
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